HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The expression of redox proteins in phyllodes tumor.

Abstract
This study aimed to investigate the associations between the expression of redox-related proteins which regulate reactive oxygen species (ROS) production and the histologic factors in phyllodes tumor (PT). We used tissue microarrays to analyze 193 PTs and performed immunohistochemical staining against five redox-related proteins including catalase, thioredoxin reductase (TxNR), glutathione S-transferase π (GST π), thioredoxin interacting protein (TxNIP), and manganese superoxide dismutase (MnSOD). We then compared the immunohistochemical results and histologic parameters. The 193 PTs were classified as benign (n = 145, 75.1 %), borderline (n = 33, 17.1 %), and malignant (n = 15, 7.8 %). With worsening histologic grade, the expression of catalase, TxNR, TxNIP, and MnSOD in the stromal component increased (P < 0.001), and GST π and MnSOD expression in the epithelial component increased (P = 0.014, and 0.038). Significant associations were found between the expression of catalse-TxNR, catalase-TxNIP, catalase-MnSOD, TxNR-TxNIP, TxNR-MnSOD, and TxNIP-MnSOD in both the epithelial and stromal components (P < 0.05). This study confirmed that the stromal expression of catalase, TxNR, TxNIP, and MnSOD increased with worsening histologic grade in PT, reflecting the change in ROS production during the malignant transformation of PT.
AuthorsSewha Kim, Do Hee Kim, Woo Hee Jung, Ja Seung Koo
JournalBreast cancer research and treatment (Breast Cancer Res Treat) Vol. 141 Issue 3 Pg. 365-74 (Oct 2013) ISSN: 1573-7217 [Electronic] Netherlands
PMID24068538 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carrier Proteins
  • TXNIP protein, human
  • Catalase
  • Superoxide Dismutase
  • TXNRD1 protein, human
  • Thioredoxin Reductase 1
  • GSTP1 protein, human
  • Glutathione S-Transferase pi
Topics
  • Adult
  • Breast Neoplasms (enzymology, pathology)
  • Carrier Proteins (metabolism)
  • Catalase (metabolism)
  • Epithelial Cells (enzymology)
  • Female
  • Glutathione S-Transferase pi (metabolism)
  • Humans
  • Middle Aged
  • Neoplasm Grading
  • Oxidation-Reduction
  • Phyllodes Tumor (enzymology, pathology)
  • Stromal Cells (enzymology)
  • Superoxide Dismutase (metabolism)
  • Thioredoxin Reductase 1 (metabolism)
  • Tissue Array Analysis

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: