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The CCHamide 1 receptor modulates sensory perception and olfactory behavior in starved Drosophila.

Abstract
The olfactory response of the vinegar fly Drosophila melanogaster to food odor is modulated by starvation. Here we show that this modulation is not restricted to food odors and their detecting sensory neurons but rather increases the behavioral response to odors as different as food odors, repellents and pheromones. The increased behavioral responsiveness is paralleled by an increased physiological sensitivity of sensory neurons regardless whether they express olfactory or ionotropic receptors and regardless whether they are housed in basiconic, coeloconic, or trichoid sensilla. Silencing several genes that become up-regulated under starvation confirmed the involvement of the short neuropeptide f receptor in the starvation effect. In addition it revealed that the CCHamide-1 receptor is another important factor governing starvation-induced olfactory modifications.
AuthorsAbu Farhan, Jyotasana Gulati, Ewald Groβe-Wilde, Heiko Vogel, Bill S Hansson, Markus Knaden
JournalScientific reports (Sci Rep) Vol. 3 Pg. 2765 ( 2013) ISSN: 2045-2322 [Electronic] England
PMID24067446 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CCHamide1r protein, Drosophila
  • Drosophila Proteins
  • Neuropeptides
  • Receptors, Odorant
Topics
  • Action Potentials (drug effects, physiology)
  • Animals
  • Behavior, Animal (physiology)
  • Drosophila Proteins (genetics, metabolism)
  • Drosophila melanogaster (drug effects, genetics, physiology)
  • Feeding Behavior (drug effects)
  • Genes, Insect
  • Neuropeptides (pharmacology)
  • Olfactory Receptor Neurons (drug effects, metabolism)
  • Receptors, Odorant (genetics, metabolism)
  • Smell (drug effects, physiology)
  • Starvation (physiopathology)

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