Abstract |
The 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine ( MPTP)-induced parkinsonism model, particularly in non-human primates, remains the gold-standard for studying the pathogenesis and assessing novel therapies for Parkinson's disease. However, whether the loss of dopaminergic neurons in this model is progressive remains controversial, mostly due to the lack of objective in vivo assessment of changes in the integrity of these neurons. In the present study, parkinsonism was induced in cynomolgus monkeys by intravenous administration of MPTP (0.2 mg/kg) for 15 days; stable parkinsonism developed over 90 days, when the symptoms were stable. Noninvasive positron emission tomographic neuroimaging of vesicular monoamine transporter 2 with 9-[(18)F] fluoropropyl-(+)- dihydrotetrabenazine ([(18)F] AV-133) was used before, and 15 and 90 days after the beginning of acute MPTP treatment. The imaging showed evident progressive loss of striatal uptake of [(18)F] AV-133. The dopaminergic denervation severity had a significant linear correlation with the clinical rating scores and the bradykinesia subscores. These findings demonstrated that [(18)F] AV-133 PET imaging is a useful tool to noninvasively evaluate the evolution of monoaminergic terminal loss in a monkey model of MPTP-induced parkinsonism.
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Authors | Yajing Liu, Feng Yue, Rongping Tang, Guoxian Tao, Xiaomei Pan, Lin Zhu, Hank F Kung, Piu Chan |
Journal | Neuroscience bulletin
(Neurosci Bull)
Vol. 30
Issue 3
Pg. 409-16
(Jun 2014)
ISSN: 1995-8218 [Electronic] Singapore |
PMID | 24061965
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fluorine Radioisotopes
- Vesicular Monoamine Transport Proteins
- florbenazine F 18
- Dopamine
- Tetrabenazine
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Topics |
- Animals
- Corpus Striatum
(diagnostic imaging, metabolism)
- Disease Models, Animal
- Dopamine
(metabolism)
- Female
- Fluorine Radioisotopes
- Linear Models
- Macaca fascicularis
- Male
- Parkinsonian Disorders
(chemically induced, diagnostic imaging, pathology)
- Positron-Emission Tomography
- Severity of Illness Index
- Tetrabenazine
(analogs & derivatives)
- Time Factors
- Vesicular Monoamine Transport Proteins
(metabolism)
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