Hemostatic efficacy of a traditional medicinal plant extract (Ankaferd Blood Stopper) in bleeding control.

Abstract

The aim of this study is to assess the in vivo hemostatic effect of Ankaferd Blood Stopper (ABS) on rats using a tail bleeding model. Wistar rats were randomized into 4 groups of 9 each: group 1, control, no pretreatment, irrigated with saline; group 2, no pretreatment, irrigated with ABS; group 3, control, heparin pretreatment, irrigated with saline; and group 4, heparin pretreatment, irrigated with ABS. To control bleeding, compressive dressings were placed after instilling 1 mL of either ABS or saline to the bleeding area. Without heparin pretreatment, ABS shortened hemostasis time by 1.57 minutes and reduced the amount of bleeding by 0.85 g. With heparin pretreatment, ABS shortened hemostasis time by 3.29 minutes and reduced the amount of bleeding by 1.32 g. The ABS was more effective than saline irrigation for treating tail tip bleeding in rats, with or without heparin pretreatment, while also using a compressive dressing.

• Authors: Ozgur Sogut, Mehmet Ozgur Erdogan, Rustu Kose, Mehmet Emin Boleken, Halil Kaya, Mehmet Tahir Gokdemir, Abdullah Ozgonul, Ismail Iynen, Levent Albayrak, Mehmet Akif Dokuzoglu
• Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) Vol. 21 Issue 4 Pg. 348-53 (May 2015) ISSN: 1938-2723 [Electronic] United States
• PMID: 24057394 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2013.

Chemical References

• Hemostatics
• Plant Extracts
• ankaferd blood stopper

Topics

• Animals
• Hemorrhage (therapy)
• Hemostatics (therapeutic use)
• Occlusive Dressings
• Plant Extracts (pharmacology)
• Rats
• Rats, Wistar
• Time Factors