The association of polymorphisms of the vitamin D receptor gene with psoriasis in the Han population of northeastern China.

Abstract

BACKGROUND:

The vitamin D receptor (VDR) is a master regulator of epidermal barrier function, inflammation, stem-cell proliferation, and microbial defense.

OBJECTIVE:

To evaluate the association between the VDR and psoriasis in the northeastern Chinese Han population.

METHODS:

In this case-control study, 342 patients with psoriasis and 341 controls were genotyped for five common VDR gene polymorphisms (ApaI, TaqI, BsmI, FokI, and Cdx2) by the Multiplex SNapSHOT method.

RESULTS:

The frequency of ApaI (rs7975232) allele A was significantly increased in psoriasis relative to the control group (27.8% vs. 22.1%, p=0.018); the allele A of the ApaI polymorphism showed a 1.35-fold increased risk of developing psoriasis. Haplotype analyses showed the BsmI/ApaI/TaqI/Cdx2/FokI GATGC to be significantly over-represented in psoriasis patients compared with controls (p=0.012). The BsmI/ApaI/TaqI haplotype GCT was presented to a lesser extent in psoriasis patients in comparison with control patients (72.2% vs. 77.9%, p=0.012).

CONCLUSIONS:

These data suggest that VDR polymorphisms are associated with psoriasis in Northeastern Han Chinese population.

• Authors: Xing Zhou, Li-dan Xu, Yu-zhen Li
• Journal: Journal of dermatological science (J Dermatol Sci) Vol. 73 Issue 1 Pg. 63-6 (Jan 2014) ISSN: 1873-569X [Electronic] Netherlands
• PMID: 24055231 (Publication Type: Journal Article)
• Copyright: Crown Copyright © 2013. Published by Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Receptors, Calcitriol
• VDR protein, human

Topics

• Adult
• Asian People (genetics)
• Case-Control Studies
• China (epidemiology)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Haplotypes
• Humans
• Male
• Middle Aged
• Phenotype
• Polymorphism, Genetic
• Psoriasis (ethnology, genetics)
• Receptors, Calcitriol (genetics)
• Risk Factors
• Young Adult