Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation.

Abstract

Of 235 Mycobacterium tuberculosis isolates from patients who had not received tuberculosis treatment in the Irkutsk oblast and the Sakha Republic (Yakutia), eastern Siberia, 61 (26%) were multidrug resistant. A novel strain, S 256, clustered among these isolates and carried eis-related kanamycin resistance, indicating a need for locally informed diagnosis and treatment strategies.

• Authors: Svetlana Zhdanova, Scott K Heysell, Oleg Ogarkov, Galina Boyarinova, Galina Alexeeva, Suporn Pholwat, Elena Zorkaltseva, Eric R Houpt, Eugeniy Savilov
• Journal: Emerging infectious diseases (Emerg Infect Dis) Vol. 19 Issue 10 Pg. 1649-52 (Oct 2013) ISSN: 1080-6059 [Electronic] United States
• PMID: 24047678 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antitubercular Agents
• Bacterial Proteins
• rpoB protein, Mycobacterium tuberculosis
• Oxidoreductases
• Catalase
• katG protein, Mycobacterium tuberculosis
• InhA protein, Mycobacterium
• EmbB protein, Mycobacterium tuberculosis
• Pentosyltransferases
• DNA-Directed RNA Polymerases
• Amidohydrolases
• PncA protein, Mycobacterium tuberculosis
• DNA Gyrase

Topics

• Adult
• Amidohydrolases (genetics)
• Amino Acid Substitution
• Antitubercular Agents (pharmacology)
• Bacterial Proteins (genetics)
• Bacterial Typing Techniques
• Catalase (genetics)
• Cluster Analysis
• DNA Gyrase (genetics)
• DNA-Directed RNA Polymerases
• Drug Resistance, Multiple, Bacterial (genetics)
• Genes, Bacterial
• Humans
• Minisatellite Repeats
• Multilocus Sequence Typing
• Mycobacterium tuberculosis (genetics)
• Oxidoreductases (genetics)
• Pentosyltransferases (genetics)
• Prevalence
• Siberia (epidemiology)
• Tuberculosis, Multidrug-Resistant (epidemiology, microbiology)
• Tuberculosis, Pulmonary (epidemiology, microbiology)