Abstract | OBJECTIVES: METHODS: The epithelial expression of syndecan-1 was examined in tissue microarrays constructed from 62 consecutive breast carcinoma cases diagnosed between 1997 and 2004 with distant organ metastasis and 10 consecutive control cases ( breast carcinoma with no distant metastasis after at least 8 years of follow-up). The prognostic significance of syndecan-1 was estimated by utilizing a Cox proportional hazards regression model. RESULTS: Among tumors with distant metastasis, syndecan-1 expression was significantly associated with a higher histologic grade and inversely related to hormonal receptor status. The HER2 subtype and triple-negative carcinomas exhibited markedly higher syndecan-1 levels than those of luminal subtypes, while the latter remained significantly higher than nonmetastatic control cases. Furthermore, high syndecan-1 expression had a negative impact on both overall and disease-free survival rates. CONCLUSIONS: These findings suggest that syndecan-1 may regulate breast cancer cell behavior and thus deserves further investigation to ascertain its potential as a therapeutic target, especially in metastatic, triple-negative carcinomas.
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Authors | Thuy L Nguyen, William E Grizzle, Kui Zhang, Omar Hameed, Gene P Siegal, Shi Wei |
Journal | American journal of clinical pathology
(Am J Clin Pathol)
Vol. 140
Issue 4
Pg. 468-74
(Oct 2013)
ISSN: 1943-7722 [Electronic] England |
PMID | 24045542
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- SDC1 protein, human
- Syndecan-1
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(metabolism, mortality, pathology)
- Carcinoma, Ductal, Breast
(metabolism, mortality, secondary)
- Carcinoma, Lobular
(metabolism, mortality, secondary)
- Female
- Humans
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
- Middle Aged
- Neoplasm Grading
- Prognosis
- Proportional Hazards Models
- Survival Rate
- Syndecan-1
(metabolism)
- Tennessee
(epidemiology)
- Tissue Array Analysis
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