Abstract | BACKGROUND AND OBJECTIVE: PATIENTS AND METHODS: Retrospective, consecutive case series of all patients treated with anti- VEGF injection for neovascular AMD at the Penn State Hershey Eye Center between 2004 and 2010: 1,710 anti- VEGF injections performed in 228 eyes of 191 patients. Each injection was analyzed according to whether the patient was taking systemic anticoagulant medication at the time of injection. RESULTS: Intraocular hemorrhage occurred after intravitreal anti- VEGF injection in four eyes (0.25%). Vitreous hemorrhage occurred in three patients taking systemic anticoagulation. Subretinal hemorrhage occurred in one patient not on anticoagulant therapy. In a bivariate analysis, the odds of intraocular hemorrhage are 1.9 times higher for injections performed in patients on systemic anticoagulation versus those not on systemic anticoagulation; this difference is not statistically significant. CONCLUSION:
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Authors | Joanna M Olson, Ingrid U Scott, Denise L Kerchner, Allen R Kunselman |
Journal | Ophthalmic surgery, lasers & imaging retina
(Ophthalmic Surg Lasers Imaging Retina)
2013 Sep-Oct
Vol. 44
Issue 5
Pg. 455-9
ISSN: 2325-8179 [Electronic] United States |
PMID | 24044707
(Publication Type: Journal Article)
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Copyright | Copyright 2013, SLACK Incorporated. |
Chemical References |
- Angiogenesis Inhibitors
- Anticoagulants
- Vascular Endothelial Growth Factor A
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Topics |
- Aged
- Aged, 80 and over
- Angiogenesis Inhibitors
(administration & dosage, adverse effects)
- Anticoagulants
(adverse effects)
- Eye Hemorrhage
(chemically induced)
- Female
- Humans
- Intravitreal Injections
(adverse effects)
- Macular Degeneration
(drug therapy)
- Male
- Middle Aged
- Retinal Hemorrhage
(chemically induced)
- Retrospective Studies
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
- Vitreous Hemorrhage
(chemically induced)
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