[Diagnostic value of BRAFV600E and RET/PTC oncogenes in thyroid nodule aspirates].

Abstract

Fine-needle aspiration cytology (FNC) is the primary means to distinguish benign form malignant nodules. Aim of this study is to evaluate the diagnostic value of BRAF(V600E) and RET/PTC oncogenes in a large cohort of thyroid nodules with inconclusive FNC. We searched for BRAF(V600E) and RET/PTC in 299 thyroid nodule aspirates then removed by surgery. RET/PTC demonstrated a poor specificity. The search for BRAF(V600E) demonstrated to be useful in 25 cases, identifying a PTC in 2 false negative, 2 inadequate, 11 indeterminate and 10 suspicious FNC. Detection of BRAF(V600E) revealed to be a useful tool to refine inconclusive cytology.

• Authors: Anna Guerra, Mario Carrano, Elisabetta Angrisani, Mario Vitale
• Journal: Recenti progressi in medicina (Recenti Prog Med) Vol. 104 Issue 7-8 Pg. 415-9 ( 2013) ISSN: 0034-1193 [Print] Italy
• Vernacular Title: Valore diagnostico degli oncogeni BRAFV600E e RET/PTC nei noduli tiroidei.
• PMID: 24042420 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Biomarkers, Tumor
• DNA, Neoplasm
• Oncogene Proteins, Fusion
• Protein-Tyrosine Kinases
• ret-PTC fusion oncoproteins, human
• BRAF protein, human
• Proto-Oncogene Proteins B-raf

Topics

• Adenocarcinoma, Follicular (chemistry, diagnosis, genetics, pathology, surgery)
• Biomarkers, Tumor (analysis)
• Biopsy, Fine-Needle
• Carcinoma, Papillary (chemistry, diagnosis, genetics, pathology, surgery)
• DNA, Neoplasm (genetics)
• Diagnosis, Differential
• Humans
• Mutation, Missense
• Oncogene Proteins, Fusion (genetics)
• Oncogenes
• Point Mutation
• Protein-Tyrosine Kinases (genetics)
• Proto-Oncogene Proteins B-raf (genetics)
• Retrospective Studies
• Sensitivity and Specificity
• Thyroid Diseases (diagnosis, genetics, pathology, surgery)
• Thyroid Neoplasms (chemistry, diagnosis, genetics, pathology, surgery)
• Thyroid Nodule (chemistry, genetics, pathology, surgery)
• Thyroidectomy