[Cardiac sympathetic innervation imaging with myocardial MIBG scintigraphy].

Abstract

Metaiodobenzylguanidine (MIBG) was developed initially as a tracer for oncological imaging; when labeled with 123 I or 131 I, it may detect APUDomas, such as pheochromocytomas and paragangliomas. In the last years, MIBG has found an important role also in neurology and cardiology, as cardiac innervation tracer. Actually, MIBG cardiac imaging is a universally accepted method to estimate cardiac sympathetic innervations. This review covers the role of MIBG cardiac imaging in Parkinson disease and parkinsonisms, from the pathophysiological premises for cardiac denervation to new emerging data.

• Authors: Eugenio Annibale Genovese, Vania Mallardo, Stefania Cipullo, Antonino Restuccia, Domenico Galea, Gianfranco D'Agosto, Imma Di Lanno, Salvatore Cappabianca
• Journal: Recenti progressi in medicina (Recenti Prog Med) 2013 Jul-Aug Vol. 104 Issue 7-8 Pg. 356-60 ISSN: 0034-1193 [Print] Italy
• Vernacular Title: Studio dell'innervazione cardiaca mediante scintigrafia miocardica con MIBG.
• PMID: 24042407 (Publication Type: Journal Article, Review)

Chemical References

• Iodine Radioisotopes
• Radiopharmaceuticals
• 3-Iodobenzylguanidine

Topics

• 3-Iodobenzylguanidine (pharmacokinetics)
• Diagnosis, Differential
• Heart (innervation)
• Heart Conduction System (diagnostic imaging)
• Humans
• Iodine Radioisotopes (pharmacokinetics)
• Lewy Body Disease (diagnosis)
• Multiple System Atrophy (diagnosis)
• Parkinson Disease (diagnostic imaging, physiopathology)
• Parkinsonian Disorders (diagnostic imaging, physiopathology)
• Presynaptic Terminals (diagnostic imaging)
• Radiopharmaceuticals (pharmacokinetics)
• Supranuclear Palsy, Progressive (diagnosis)
• Sympathectomy
• Sympathetic Fibers, Postganglionic (diagnostic imaging)
• Sympathetic Nervous System (diagnostic imaging)
• Tomography, Emission-Computed, Single-Photon (methods)