| Abstract |
A new paullone- TEMPO conjugate and its copper(II) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines. |
| Authors | Anatolie Dobrov, Simone Göschl, Michael A Jakupec, Ana Popović-Bijelić, Astrid Gräslund, Peter Rapta, Vladimir B Arion |
| Journal | Chemical communications (Cambridge, England)
(Chem Commun (Camb))
Vol. 49
Issue 85
Pg. 10007-9
(Nov 04 2013)
ISSN: 1364-548X [Electronic] England |
| PMID | 24042148
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antineoplastic Agents
- Benzazepines
- Coordination Complexes
- Cyclic N-Oxides
- Free Radicals
- Ligands
- NR2E3 protein, human
- Orphan Nuclear Receptors
- Reactive Oxygen Species
- paullone
- Copper
- TEMPO
|
| Topics |
- Antineoplastic Agents
(chemistry, pharmacology)
- Apoptosis
(drug effects)
- Benzazepines
(chemistry, pharmacology)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Coordination Complexes
(chemistry, pharmacology)
- Copper
(chemistry)
- Cyclic N-Oxides
(chemistry)
- Free Radicals
(chemistry)
- Humans
- Inhibitory Concentration 50
- Ligands
- Molecular Structure
- Orphan Nuclear Receptors
(antagonists & inhibitors)
- Reactive Oxygen Species
|
