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In vitro susceptibility of Aspergillus fumigatus to isavuconazole: correlation with itraconazole, voriconazole, and posaconazole.

Abstract
Triazoles are first-line agents for treating aspergillosis. The prevalence of azole resistance in Aspergillus fumigatus is increasing, and cross-resistance is a growing concern. In this study, the susceptibilities of 40 A. fumigatus clinical isolates were tested by using the CLSI method with amphotericin B, itraconazole, voriconazole, posaconazole, and the new triazole isavuconazole. Isavuconazole MICs were higher in strains with reduced susceptibilities to other triazoles, mirroring changes in voriconazole susceptibility. Isavuconazole MICs differed depending on the Cyp51A substitution.
AuthorsLea Gregson, Joanne Goodwin, Adam Johnson, Laura McEntee, Caroline B Moore, Malcolm Richardson, William W Hope, Susan J Howard
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 57 Issue 11 Pg. 5778-80 (Nov 2013) ISSN: 1098-6596 [Electronic] United States
PMID24041890 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Antifungal Agents
  • Fungal Proteins
  • Nitriles
  • Pyridines
  • Pyrimidines
  • Triazoles
  • Itraconazole
  • isavuconazole
  • posaconazole
  • Amphotericin B
  • Cytochrome P-450 Enzyme System
  • cytochrome P-450 CYP51A, Aspergillus
  • Voriconazole
Topics
  • Amino Acid Substitution
  • Amphotericin B (pharmacology)
  • Antifungal Agents (pharmacology)
  • Aspergillus fumigatus (drug effects, genetics, growth & development, metabolism)
  • Cytochrome P-450 Enzyme System (genetics, metabolism)
  • Drug Resistance, Fungal (genetics)
  • Fungal Proteins (genetics, metabolism)
  • Humans
  • Itraconazole (pharmacology)
  • Microbial Sensitivity Tests
  • Mutation
  • Nitriles (pharmacology)
  • Pyridines (pharmacology)
  • Pyrimidines (pharmacology)
  • Triazoles (pharmacology)
  • Voriconazole

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