Glutathione S-transferase T1, O1 and O2 polymorphisms are associated with survival in muscle invasive bladder cancer patients.

Abstract

OBJECTIVE:

To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy.

PATIENTS AND METHODS:

A total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival.

RESULTS:

GSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006).

CONCLUSION:

GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer.

• Authors: Tatjana I Djukic, Ana R Savic-Radojevic, Tatjana D Pekmezovic, Marija G Matic, Marija S Pljesa-Ercegovac, Vesna M Coric, Tanja M Radic, Sonja R Suvakov, Biljana N Krivic, Dejan P Dragicevic, Tatjana P Simic
• Journal: PloS one (PLoS One) Vol. 8 Issue 9 Pg. e74724 ( 2013) ISSN: 1932-6203 [Electronic] United States
• PMID: 24040330 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• glutathione S-transferase T1
• GSTO1 protein, human
• GSTO2 protein, human
• Glutathione Transferase

Topics

• Aged
• Antineoplastic Agents (therapeutic use)
• Female
• Genotype
• Glutathione Transferase (genetics)
• Humans
• Male
• Middle Aged
• Neoplasm Invasiveness
• Pharmacogenetics
• Polymorphism, Genetic
• Prognosis
• Proportional Hazards Models
• Treatment Outcome
• Urinary Bladder Neoplasms (drug therapy, genetics, mortality)