Abstract | BACKGROUND: METHODS: RESULTS: Pigs treated with ETT KL4 S and AERO KL4 S had improved survival and sustained pO2 compared to controls. The AERO KL4 S group had higher pH compared to controls. Lung IL-8 levels were lower in the AERO KL4 S group compared to controls. Histomorphometric analysis showed less hemorrhage in the ETT and AERO KL4 S groups compared to controls. The AERO KL4 S group had more open lung units per fixed-field than the ETT KL4 S or controls. CONCLUSIONS: AERO KL4 S produced similar improvements in survival, physiology, inflammatory markers, and morphology as ETT KL4 S in an ALI model.
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Authors | Andrea L Lampland, Marla R Wolfson, Jan Mazela, Christopher Henderson, Timothy J Gregory, Patricia Meyers, Brenda Plumm, Cathy Worwa, Mark C Mammel |
Journal | Pediatric pulmonology
(Pediatr Pulmonol)
Vol. 49
Issue 5
Pg. 482-9
(May 2014)
ISSN: 1099-0496 [Electronic] United States |
PMID | 24039229
(Publication Type: Journal Article)
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Copyright | © 2013 Wiley Periodicals, Inc. |
Chemical References |
- Aerosols
- Intercellular Signaling Peptides and Proteins
- Interleukin-8
- KL4 surfactant
- Peptides
- Peroxidase
- Hydrochloric Acid
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Topics |
- Acute Lung Injury
(chemically induced, metabolism, pathology)
- Administration, Inhalation
- Aerosols
(pharmacology)
- Animals
- Animals, Newborn
- Continuous Positive Airway Pressure
- Disease Models, Animal
- Hydrochloric Acid
(toxicity)
- Intercellular Signaling Peptides and Proteins
- Interleukin-8
(drug effects, metabolism)
- Lung
(drug effects, metabolism, pathology)
- Peptides
(pharmacology)
- Peroxidase
(drug effects, metabolism)
- Pulmonary Gas Exchange
(drug effects)
- Random Allocation
- Survival Rate
- Swine
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