Water-soluble polymers coupled with glycopeptide antigens and T-cell epitopes as potential antitumor vaccines.

Abstract

Highly decorated: Tumor-associated MUC1 glycopeptide and tetanus toxoid T-cell epitope P2 can be attached to water-soluble poly(N-(2-hydroxypropyl)methacrylamide) carriers by orthogonal ligation techniques. Fully synthetic vaccine A with additional nanostructure-promoting domains induced antibodies that exhibit high affinity to tumor cells.

• Authors: Lutz Nuhn, Sebastian Hartmann, Björn Palitzsch, Bastian Gerlitzki, Edgar Schmitt, Rudolf Zentel, Horst Kunz
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 52 Issue 40 Pg. 10652-6 (Sep 27 2013) ISSN: 1521-3773 [Electronic] Germany
• PMID: 24038824 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Cancer Vaccines
• Epitopes, T-Lymphocyte
• Glycopeptides
• MUC1 protein, human
• Mucin-1
• Polymethacrylic Acids
• Vaccines, Synthetic
• Water
• Duxon

Topics

• Amino Acid Sequence
• Animals
• Cancer Vaccines (chemistry, immunology)
• Epitopes, T-Lymphocyte (chemistry, immunology)
• Glycopeptides (chemistry, immunology)
• Humans
• MCF-7 Cells
• Mice
• Molecular Sequence Data
• Mucin-1 (chemistry, immunology)
• Polymethacrylic Acids (chemistry)
• Solubility
• T-Lymphocytes, Helper-Inducer (immunology)
• Vaccines, Synthetic (chemistry, immunology)
• Water (chemistry)