Abstract |
Undifferentiated embryonal sarcoma of the liver (UESL) is an uncommon hepatic tumor usually found in children, with rare cases reported in adults. We present a case of a 53-year-old woman with an undifferentiated sarcoma of the liver (USL), which resembles UESL, who initially presented with a markedly elevated hematocrit (61.2%). Cytogenetic studies for polycythemia vera were negative, but the patient's erythropoietin (EPO) was elevated. A computed tomography scan and subsequent partial hepatectomy revealed a well-circumscribed, partially cystic mass in the right lobe of the liver measuring 34 cm. Following surgery, the patient's EPO level and hematocrit dropped to within normal range and remained so for 1 year, at which point it rose again. A subsequent magnetic resonance imaging scan showed a liver mass at the previous resection margin, consistent with a recurrence. In this case study, we describe the first reported USL resembling an UESL that secretes EPO, which was a useful marker of tumor recurrence.
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Authors | JoAnn M Lin, Jonathon E Heath, William S Twaddell, Rudy J Castellani |
Journal | International journal of surgical pathology
(Int J Surg Pathol)
Vol. 22
Issue 6
Pg. 555-8
(Sep 2014)
ISSN: 1940-2465 [Electronic] United States |
PMID | 24038117
(Publication Type: Case Reports, Journal Article)
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Copyright | © The Author(s) 2013. |
Chemical References |
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Topics |
- Erythropoietin
(metabolism)
- Female
- Humans
- Liver Neoplasms
(metabolism, pathology)
- Middle Aged
- Neoplasm Recurrence, Local
(metabolism, pathology)
- Sarcoma
(metabolism, pathology)
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