HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Undifferentiated sarcoma of the liver: a case study of an erythropoietin-secreting tumor.

Abstract
Undifferentiated embryonal sarcoma of the liver (UESL) is an uncommon hepatic tumor usually found in children, with rare cases reported in adults. We present a case of a 53-year-old woman with an undifferentiated sarcoma of the liver (USL), which resembles UESL, who initially presented with a markedly elevated hematocrit (61.2%). Cytogenetic studies for polycythemia vera were negative, but the patient's erythropoietin (EPO) was elevated. A computed tomography scan and subsequent partial hepatectomy revealed a well-circumscribed, partially cystic mass in the right lobe of the liver measuring 34 cm. Following surgery, the patient's EPO level and hematocrit dropped to within normal range and remained so for 1 year, at which point it rose again. A subsequent magnetic resonance imaging scan showed a liver mass at the previous resection margin, consistent with a recurrence. In this case study, we describe the first reported USL resembling an UESL that secretes EPO, which was a useful marker of tumor recurrence.
AuthorsJoAnn M Lin, Jonathon E Heath, William S Twaddell, Rudy J Castellani
JournalInternational journal of surgical pathology (Int J Surg Pathol) Vol. 22 Issue 6 Pg. 555-8 (Sep 2014) ISSN: 1940-2465 [Electronic] United States
PMID24038117 (Publication Type: Case Reports, Journal Article)
Copyright© The Author(s) 2013.
Chemical References
  • Erythropoietin
Topics
  • Erythropoietin (metabolism)
  • Female
  • Humans
  • Liver Neoplasms (metabolism, pathology)
  • Middle Aged
  • Neoplasm Recurrence, Local (metabolism, pathology)
  • Sarcoma (metabolism, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: