Abstract | BACKGROUND: METHODS: Positron emission tomography imaging with the radiotracer [(11)C] ABP688 was used to measure mGluR5 binding and magnetic resonance spectroscopy was used to measure glutamate- glutamine levels in the striatum of cocaine-addicted participants (n = 15) compared with healthy control subjects (n = 15). Following the scans, the cocaine-addicted volunteers performed cocaine self-administration sessions to investigate the correlation between cocaine-seeking behavior and mGluR5 receptor binding. RESULTS: The results of the study showed that cocaine addiction was associated with a 20% to 22% reduction in [(11)C] ABP688 binding in the striatum. A secondary analysis of cortical and subcortical regions other than the striatum showed a similar reduction in [(11)C] ABP688 binding, suggesting that the decrease was widespread. No between-group differences were seen in the magnetic resonance spectroscopy measures of glutamate- glutamine in the left striatum. In addition, no correlation was seen between [(11)C] ABP688 binding in the striatum and the choice to self-administer cocaine. CONCLUSIONS: Overall, these results show that long-term cocaine use is associated with a decrease in mGluR5 availability compared with matched healthy control subjects and suggests that this receptor may serve as a viable target for treatment development for this disorder.
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Authors | Diana Martinez, Mark Slifstein, Nabeel Nabulsi, Alexander Grassetti, Nina B L Urban, Audrey Perez, Fei Liu, Shu-Fei Lin, Jim Ropchan, Xiangling Mao, Lawrence S Kegeles, Dikoma C Shungu, Richard E Carson, Yiyun Huang |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 75
Issue 2
Pg. 165-71
(Jan 15 2014)
ISSN: 1873-2402 [Electronic] United States |
PMID | 24035345
(Publication Type: Journal Article, Observational Study, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2014 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- 3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloxime
- Carbon Radioisotopes
- Oximes
- Pyridines
- Receptor, Metabotropic Glutamate 5
- Glutamine
- Glutamic Acid
- Cocaine
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Topics |
- Adult
- Brain
(diagnostic imaging, metabolism)
- Carbon Radioisotopes
- Case-Control Studies
- Choice Behavior
(drug effects)
- Cocaine
(administration & dosage)
- Cocaine-Related Disorders
(diagnostic imaging, metabolism)
- Corpus Striatum
(diagnostic imaging, metabolism)
- Functional Neuroimaging
- Glutamic Acid
(metabolism)
- Glutamine
(metabolism)
- Homeostasis
- Humans
- Magnetic Resonance Spectroscopy
- Male
- Oximes
- Positron-Emission Tomography
- Pyridines
- Receptor, Metabotropic Glutamate 5
(metabolism)
- Self Administration
- Young Adult
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