Abstract | CONTEXT: OBJECTIVE: The present study determined the effects of HSYA on left ventricular hypertrophy after pressure overload and investigated the underlying mechanisms. MATERIALS AND METHODS: RESULTS: HSYA (20, 40 mg/kg) significantly attenuated the increase of LVMI (ventricular weight/body weight) by 13.04 and 30.43% respectively, when compared with the model group. This was associated with the amelioration of pathological lesion, such as cardiac muscle fibers were smaller and the nuclei of cardiomyocytes were lightly stained in animals treated with HSYA (20, 40 mg/kg). In addition, the administration of HSYA at doses of 20 and 40 mg/kg increased the Bcl-2/Bax ratio (1.17 ± 0.08 and 1.39 ± 0.07 versus 0.71 ± 0.06). In addition, the serum MMP-2 and MMP-9 levels were blocked by the treatment at doses of 20 and 40 mg/kg HSYA ( MMP-2, 76.1 ± 9.2 and 65.6 ± 6.8 versus 82.9 ± 6.2, ng/ml; MMP-9, 66.6 ± 4.8 and 57.5 ± 5.0 versus 83.5 ± 6.0, ng/ml). CONCLUSION: These findings indicated that HSYA has beneficial effects on hypertensive ventricular remodeling, which may involve mechanisms of inhibiting cell apoptosis and suppressing metalloproteinases expression.
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Authors | Jianping Wang, Qing Zhang, Xiuhua Mei, Xiuzhen Zhang |
Journal | Pharmaceutical biology
(Pharm Biol)
Vol. 52
Issue 1
Pg. 31-5
(Jan 2014)
ISSN: 1744-5116 [Electronic] England |
PMID | 24033225
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Quinones
- hydroxysafflor yellow A
- Chalcone
- Captopril
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
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Topics |
- Animals
- Apoptosis
(drug effects)
- Captopril
(pharmacology)
- Cardiomegaly
(drug therapy, physiopathology)
- Carthamus tinctorius
(chemistry)
- Chalcone
(administration & dosage, analogs & derivatives, isolation & purification, pharmacology)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Enzyme-Linked Immunosorbent Assay
- Hypertension
(complications, drug therapy)
- Male
- Matrix Metalloproteinase 2
(metabolism)
- Matrix Metalloproteinase 9
(metabolism)
- Medicine, Chinese Traditional
- Myocytes, Cardiac
(drug effects, metabolism)
- Quinones
(administration & dosage, isolation & purification, pharmacology)
- Rats
- Rats, Wistar
- Ventricular Remodeling
(drug effects)
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