Abstract |
Benzopyran derivatives are the potassium channel openers (KCOs) having antihypertensive, cardio-protective, myocardial protectors, powerful peripheral vasodilators and anti-ischemic activity. Their usage as anti-ischemic including angina, hypertension and diabetes is thought to be due to the stimulation of KATP channels which are contemplated to produce vasorelaxation and myocardial protection. It is observed that potassium channels are involved in mediating the cardio-protective effects of pre-conditioning in animal models and man. KCOs protect heart from an ischemic insult without contribution from vasodilatation. This review provides an overview of the characteristics of KCOs and their actions on subtypes used widely for the treatments of various diseases including hypertension, cardiac ischemia, arrhythmia, smooth muscle relaxation, diabetes, cardio-protective and anti-angiogenic activities.
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Authors | Mohsina Bano, Kuldipsinh P Barot, Shaik Miftah Ahmed, Stoyanka Nikolova, Illiyan Ivanov, Manjunath D Ghate |
Journal | Mini reviews in medicinal chemistry
(Mini Rev Med Chem)
Vol. 13
Issue 12
Pg. 1744-60
(Oct 2013)
ISSN: 1875-5607 [Electronic] Netherlands |
PMID | 24032515
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Anti-Arrhythmia Agents
- Antihypertensive Agents
- Benzopyrans
- Cardiotonic Agents
- KATP Channels
- Vasodilator Agents
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Topics |
- Animals
- Anti-Arrhythmia Agents
(chemistry, pharmacology, therapeutic use)
- Antihypertensive Agents
(chemical synthesis, chemistry, pharmacology)
- Arrhythmias, Cardiac
(drug therapy)
- Benzopyrans
(chemical synthesis, chemistry, therapeutic use)
- Blood Pressure
(drug effects)
- Cardiotonic Agents
(chemical synthesis, chemistry, pharmacology)
- Heart
(drug effects)
- Humans
- Ischemia
(drug therapy)
- KATP Channels
(chemistry, metabolism)
- Muscle Relaxation
(drug effects)
- Vasodilator Agents
(chemistry, pharmacology, therapeutic use)
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