HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Benzopyran derivatives as cardio-selective ATP-sensitive potassium channel openers: a review.

Abstract
Benzopyran derivatives are the potassium channel openers (KCOs) having antihypertensive, cardio-protective, myocardial protectors, powerful peripheral vasodilators and anti-ischemic activity. Their usage as anti-ischemic including angina, hypertension and diabetes is thought to be due to the stimulation of KATP channels which are contemplated to produce vasorelaxation and myocardial protection. It is observed that potassium channels are involved in mediating the cardio-protective effects of pre-conditioning in animal models and man. KCOs protect heart from an ischemic insult without contribution from vasodilatation. This review provides an overview of the characteristics of KCOs and their actions on subtypes used widely for the treatments of various diseases including hypertension, cardiac ischemia, arrhythmia, smooth muscle relaxation, diabetes, cardio-protective and anti-angiogenic activities.
AuthorsMohsina Bano, Kuldipsinh P Barot, Shaik Miftah Ahmed, Stoyanka Nikolova, Illiyan Ivanov, Manjunath D Ghate
JournalMini reviews in medicinal chemistry (Mini Rev Med Chem) Vol. 13 Issue 12 Pg. 1744-60 (Oct 2013) ISSN: 1875-5607 [Electronic] Netherlands
PMID24032515 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Anti-Arrhythmia Agents
  • Antihypertensive Agents
  • Benzopyrans
  • Cardiotonic Agents
  • KATP Channels
  • Vasodilator Agents
Topics
  • Animals
  • Anti-Arrhythmia Agents (chemistry, pharmacology, therapeutic use)
  • Antihypertensive Agents (chemical synthesis, chemistry, pharmacology)
  • Arrhythmias, Cardiac (drug therapy)
  • Benzopyrans (chemical synthesis, chemistry, therapeutic use)
  • Blood Pressure (drug effects)
  • Cardiotonic Agents (chemical synthesis, chemistry, pharmacology)
  • Heart (drug effects)
  • Humans
  • Ischemia (drug therapy)
  • KATP Channels (chemistry, metabolism)
  • Muscle Relaxation (drug effects)
  • Vasodilator Agents (chemistry, pharmacology, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: