Efficacy of a new mouth rinse formulation based on 0.07% cetylpyridinium chloride in the control of plaque and gingivitis: a 6-month randomized clinical trial.

Abstract

AIM:

To assess the efficacy of a 0.07% cetylpyridinium chloride (CPC) mouth rinse in the control of plaque and gingival inflammation during a 6-month period.

MATERIAL AND METHODS:

Adult subjects with moderate gingivitis were selected [≥40% bleeding on marginal probing (BOMP)]. After retrieving microbiological samples and evaluating the clinical parameters (plaque, BOMP and stain indexes), a professional prophylaxis was performed and subjects were randomly assigned to the test (CPC mouth rinse) or to the placebo group. Subjects were re-assessed after 3 and 6 months.

RESULTS:

A total of 67 patients (35 test, 32 placebo) were included in the analysis. At 6 months, intra-group significant plaque reductions were observed in the test group (0.691, p < 0.001), but not in the placebo (0.181, p = 0.653). At 6 months, the mean BOMP values were lower in the test group (p = 0.052). Changes between baseline and 6 months were significantly higher in the test group both for plaque (p = 0.002) and BOMP (p = 0.037) when compared with the placebo. A microbiological impact was observed in the test group, especially for Prevotella intermedia.

CONCLUSION:

The evaluated 0.07% CPC-based mouth rinse, used three times per day adjunctively to mechanical tooth cleaning, prevents plaque accumulation and gingival inflammation, as compared to the placebo, for at least 6 months.

• Authors: Xavier Costa, Estefanía Laguna, David Herrera, Jorge Serrano, Bettina Alonso, Mariano Sanz
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 40 Issue 11 Pg. 1007-15 (Nov 2013) ISSN: 1600-051X [Electronic] United States
• PMID: 24024983 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Anti-Infective Agents, Local
• Mouthwashes
• Placebos
• Cetylpyridinium

Topics

• Adult
• Aggregatibacter actinomycetemcomitans (drug effects)
• Anti-Infective Agents, Local (chemistry, therapeutic use)
• Bacteroides (drug effects)
• Capnocytophaga (drug effects)
• Cetylpyridinium (chemistry, therapeutic use)
• Chemistry, Pharmaceutical
• Dental Plaque (microbiology, prevention & control)
• Double-Blind Method
• Eikenella corrodens (drug effects)
• Eubacterium (drug effects)
• Female
• Follow-Up Studies
• Fusobacterium nucleatum (drug effects)
• Gingival Hemorrhage (prevention & control)
• Gingivitis (prevention & control)
• Humans
• Male
• Middle Aged
• Mouthwashes (chemistry, therapeutic use)
• Peptostreptococcus (drug effects)
• Placebos
• Porphyromonas gingivalis (drug effects)
• Prevotella intermedia (drug effects)
• Prevotella nigrescens (drug effects)
• Treatment Outcome
• Young Adult