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Role of ascorbic acid in counteracting ferric nitrilotriacetate-induced nephrotoxicity in rats.

AbstractCONTEXT:
Ascorbic acid (AA) is a naturally occurring organic compound with antioxidant properties. It is necessary for normal growth and development, and has been shown to protect against tissue toxicity and oxidative stress.
OBJECTIVE:
The protective effect of AA against nephrotoxicity induced in albino rats by ferric nitrilotriacetate (Fe-NTA) was evaluated.
MATERIALS AND METHODS:
Male albino rats of Wistar strain (4-6 weeks old) weighing 125-150 g were used in this study. Animals were given a single dose of Fe-NTA (9 mg/kg body weight, intraperitoneal) after a week of treatment with AA (1 and 2 mg/animal/day).
RESULTS:
Fe-NTA treatment enhanced microsomal lipid peroxidation (LPO) and hydrogen peroxide (H2O2) generation to 1.7- to 2.2-fold, glutathione (GSH) levels were decreased by two-fold and the activities of GSH metabolizing enzymes decreased to a range of 2.2- to 2.5-fold in renal tissue. These changes were reversed significantly in animals receiving pretreatment of AA. Treatment of rats with AA prior to the treatment with Fe-NTA decreased microsomal LPO and H2O2 generation to 124 and 172%, and also resulted in the recovery of reduced levels of GSH, GSH-metabolizing enzymes to almost 92% at the higher dose level of AA.
DISCUSSION AND CONCLUSION:
AA protects against Fe-NTA-induced nephrotoxicity and renal damage. AA has a beneficial impact on Fe-NTA-induced toxicity due to its scavenging and antioxidant effect in albino rats.
AuthorsS Ansar, M Iqbal
JournalPharmaceutical biology (Pharm Biol) Vol. 51 Issue 12 Pg. 1559-63 (Dec 2013) ISSN: 1744-5116 [Electronic] England
PMID24024952 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Ferric Compounds
  • Glutathione Peroxidase
  • Glutathione Transferase
  • Glutathione
  • Nitrilotriacetic Acid
  • Ascorbic Acid
  • ferric nitrilotriacetate
Topics
  • Animals
  • Antioxidants (therapeutic use)
  • Ascorbic Acid (therapeutic use)
  • Ferric Compounds (toxicity)
  • Glutathione (metabolism)
  • Glutathione Peroxidase (metabolism)
  • Glutathione Transferase (metabolism)
  • Kidney Diseases (chemically induced, metabolism, prevention & control)
  • Lipid Peroxidation (drug effects)
  • Male
  • Microsomes (drug effects, metabolism)
  • Nitrilotriacetic Acid (analogs & derivatives, toxicity)
  • Oxidative Stress (drug effects)
  • Rats
  • Rats, Wistar

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