Abstract | OBJECTIVE: METHOD: Girls 13-18 years old with anorexia nervosa (DSM-IV) were randomized to transdermal estradiol (100 μg twice weekly) with cyclic progesterone or placebo patches and pills for 18-months, between 2002 and 2010. The State-Trait Anxiety Inventory for Children (STAIC), the Eating Disorders Inventory-2 (EDI-2), and the Body Shape Questionnaire (BSQ-34) were administered. 72 girls completed these measures at baseline (n=38 [girls receiving estrogen] and n=34 [girls receiving placebo]) and 37 at 18 months (n=20 [girls receiving estrogen] and n=17 [girls receiving placebo]). The primary outcome measure was the change in these scores over 18 months. RESULTS:
Estrogen replacement caused a decrease in STAIC-trait scores (-3.05 [1.22] vs. 2.07 [1.73], P=.02), without impacting STAIC-state scores (-1.11 [2.17] vs. 0.20 [1.42], P=.64). There was no effect of estrogen replacement on EDI-2 or BSQ-34 scores. Body mass index (BMI) changes did not differ between groups, and effects of estrogen replacement on STAIC-trait scores persisted after controlling for BMI changes (P=.03). Increases in serum estradiol were significantly associated with decreases in STAIC-trait scores (Spearman ρ = -0.45, P=.03). CONCLUSIONS:
Estrogen replacement improved trait anxiety (the tendency to experience anxiety) but did not impact eating attitudes or body shape perception. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00088153.
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Authors | Madhusmita Misra, Debra K Katzman, Nara Mendes Estella, Kamryn T Eddy, Thomas Weigel, Mark A Goldstein, Karen K Miller, Anne Klibanski |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 74
Issue 8
Pg. e765-71
(Aug 2013)
ISSN: 1555-2101 [Electronic] United States |
PMID | 24021517
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Copyright | © Copyright 2013 Physicians Postgraduate Press, Inc. |
Chemical References |
- Sex Hormone-Binding Globulin
- Testosterone
- Estradiol
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Topics |
- Adolescent
- Anorexia Nervosa
(blood, diagnosis, drug therapy, psychology)
- Anxiety Disorders
(blood, diagnosis, drug therapy, psychology)
- Attitude to Health
- Body Dysmorphic Disorders
(blood, diagnosis, drug therapy, psychology)
- Estradiol
(blood)
- Estrogen Replacement Therapy
- Feeding Behavior
(drug effects, psychology)
- Female
- Humans
- Reference Values
- Sex Hormone-Binding Globulin
(analysis)
- Surveys and Questionnaires
- Testosterone
(blood)
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