Impact of multimodal therapy on the survival of patients with newly diagnosed uterine carcinosarcoma.

To investigate treatment outcomes of uterine carcinosarcoma (CS) patients who underwent complete surgical resection of all visible disease and platinum-based adjuvant chemotherapy (multimodal therapy).
The authors reviewed 127 uterine CS patients treated at this institution from 1990 to 2010. They operated 123 patients in clinical Stages 1-3, 97 of which underwent complete resection and systemic lymphadenectomy.
A total of 97 patients (FIGO 2008: Stage 1 in 50 patients, Stage 2 in six, Stage 3 in 37, and Stage 4 in four) underwent surgical staging, 74 of which were administered five cycles (median) of platinum-based adjuvant chemotherapy. The median overall survival (OS) associated with multimodal therapy 50.6 months compared with 34.9 months incomplete multimodal therapy. After multimodal treatment, 32.9% (32/97) patients showed recurrence (24/32 hematogenous).
Multimodal therapy increased survival among uterine CS patients, but the recurrence rate remained high. Further consideration of treatment options for uterine CS is required.
AuthorsH Machida, K Takahashi, H Nomura, M Matoda, K Omatsu, K Kato, K Umayahara, N Takeshima
JournalEuropean journal of gynaecological oncology (Eur J Gynaecol Oncol) Vol. 34 Issue 4 Pg. 291-5 ( 2013) ISSN: 0392-2936 [Print] Italy
PMID24020131 (Publication Type: Journal Article)
  • Adult
  • Aged
  • Carcinosarcoma (mortality, pathology, therapy)
  • Combined Modality Therapy
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Prognosis
  • Uterine Neoplasms (mortality, pathology, therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: