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Impact of multimodal therapy on the survival of patients with newly diagnosed uterine carcinosarcoma.

AbstractPURPOSE:
To investigate treatment outcomes of uterine carcinosarcoma (CS) patients who underwent complete surgical resection of all visible disease and platinum-based adjuvant chemotherapy (multimodal therapy).
MATERIALS AND METHODS:
The authors reviewed 127 uterine CS patients treated at this institution from 1990 to 2010. They operated 123 patients in clinical Stages 1-3, 97 of which underwent complete resection and systemic lymphadenectomy.
RESULTS:
A total of 97 patients (FIGO 2008: Stage 1 in 50 patients, Stage 2 in six, Stage 3 in 37, and Stage 4 in four) underwent surgical staging, 74 of which were administered five cycles (median) of platinum-based adjuvant chemotherapy. The median overall survival (OS) associated with multimodal therapy 50.6 months compared with 34.9 months incomplete multimodal therapy. After multimodal treatment, 32.9% (32/97) patients showed recurrence (24/32 hematogenous).
CONCLUSION:
Multimodal therapy increased survival among uterine CS patients, but the recurrence rate remained high. Further consideration of treatment options for uterine CS is required.
AuthorsH Machida, K Takahashi, H Nomura, M Matoda, K Omatsu, K Kato, K Umayahara, N Takeshima
JournalEuropean journal of gynaecological oncology (Eur J Gynaecol Oncol) Vol. 34 Issue 4 Pg. 291-5 ( 2013) ISSN: 0392-2936 [Print] Italy
PMID24020131 (Publication Type: Journal Article)
Topics
  • Adult
  • Aged
  • Carcinosarcoma (mortality, pathology, therapy)
  • Combined Modality Therapy
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Prognosis
  • Uterine Neoplasms (mortality, pathology, therapy)

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