Effects of supplementation with fish oil and n-3 PUFAs enriched egg yolk phospholipids on anhedonic-like response and body weight in the rat chronic mild stress model of depression.

Abstract

Polyunsaturated fatty acids play an important role in the human organism. They guarantee a normal function of nervous cells, influence neurotransmission, and build some elements of cellular membranes. Several reports indicate an association between a deficiency of polyunsaturated fatty acids and depression. The aim of this study was to examine the effects of diet supplemented with fish oil, which is rich in omega-3 polyunsaturated fatty acids (n-3 PUFAs) and n-3 PUFAs enriched phospholipids ("super lecithin") obtained from designed eggs on anhedonic-like response and body weight in the rat chronic mild stress (CMS) model of depression. The results showed that neither fish oil nor n-3 PUFAs enriched egg yolk phospholipids supplementation reversed disturbances caused by CMS, such as anhedonic-like state or reduction of body weight gain.

• Authors: M Rutkowska, M Trocha, M Szandruk, W Słupski, J Rymaszewska
• Journal: Die Pharmazie (Pharmazie) Vol. 68 Issue 8 Pg. 685-8 (Aug 2013) ISSN: 0031-7144 [Print] Germany
• PMID: 24020125 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fatty Acids, Omega-3
• Fish Oils
• Lecithins
• Phospholipids

Topics

• Analysis of Variance
• Anhedonia
• Animals
• Body Weight (drug effects)
• Depression (pathology, psychology)
• Diet
• Dietary Supplements
• Egg Yolk (chemistry)
• Fatty Acids, Omega-3 (pharmacology)
• Fish Oils (pharmacology)
• Lecithins (pharmacology)
• Male
• Phospholipids (chemistry)
• Rats
• Rats, Wistar
• Stress, Psychological (drug therapy, psychology)