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Knockdown of CRM1 inhibits the nuclear export of p27(Kip1) phosphorylated at serine 10 and plays a role in the pathogenesis of epithelial ovarian cancer.

Abstract
In a previous study, the nuclear export protein chromosomal region maintenance (CRM1) was correlated with p27(Kip1) in glioma. The aims of the present study were to investigate the expression of CRM1 and pSer10p27 and their functional roles in epithelial ovarian cancer (EOC) tissues. Using immunohistochemical analysis, CRM1 and pSer10p27 expression levels were shown to be associated with histologic stage and grade (P<0.05). High CRM1 and pSer10p27 expression levels were prognostic indicators of overall survival (P<0.05). Knockdown of CRM1 and pSer10p27 expression arrested cell cycle progression and inhibited the proliferation of SKOV3 cells both in vitro and in vivo. These data support the idea that pSer10p27 and CRM1 play cooperative roles in EOC.
AuthorsYou Wang, Yingying Wang, Jingying Xiang, Fang Ji, Yan Deng, Chunhui Tang, Shuyun Yang, Qinghua Xi, Rong Liu, Wen Di
JournalCancer letters (Cancer Lett) Vol. 343 Issue 1 Pg. 6-13 (Feb 01 2014) ISSN: 1872-7980 [Electronic] Ireland
PMID24018641 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • CDKN1B protein, human
  • Karyopherins
  • Receptors, Cytoplasmic and Nuclear
  • Cyclin-Dependent Kinase Inhibitor p27
  • Serine
Topics
  • Active Transport, Cell Nucleus
  • Adult
  • Animals
  • Carcinoma, Ovarian Epithelial
  • Cell Line, Tumor
  • Cell Proliferation
  • Cyclin-Dependent Kinase Inhibitor p27 (metabolism)
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Gene Knockdown Techniques
  • Humans
  • Immunohistochemistry
  • Karyopherins (genetics, metabolism)
  • Mice
  • Microscopy, Fluorescence
  • Middle Aged
  • Neoplasm Transplantation
  • Neoplasms, Glandular and Epithelial (genetics, metabolism)
  • Ovarian Neoplasms (genetics, metabolism)
  • Phosphorylation
  • Receptors, Cytoplasmic and Nuclear (genetics, metabolism)
  • Serine (chemistry)
  • Exportin 1 Protein

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