Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.

Abstract

Based on the Wnt inhibitors as potential targets in the development of anticancer agents, natural compounds were evaluated for β-catenin-mediated transcriptional activity. A natural lignan hydnocarpin isolated from Lonicera japonica was considered a potential inhibitor for Wnt/β-catenin signalings. The anti-proliferative activity of hydnocarpin was also found to be associated with the suppression of Wnt/β-catenin-mediated signaling pathway in human colon cancer cells. These data suggest that hydnocarpin might be a novel Wnt inhibitor and has a potential of signaling regulator in β-catenin-mediated signaling pathways.

• Authors: Min-Ai Lee, Won Kyung Kim, Hyen Joo Park, Sam Sik Kang, Sang Kook Lee
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 23 Issue 20 Pg. 5511-4 (Oct 15 2013) ISSN: 1464-3405 [Electronic] England
• PMID: 24018191 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• AXIN1 protein, human
• Antineoplastic Agents, Phytogenic
• Axin Protein
• Flavonolignans
• Lignans
• RNA, Small Interfering
• Wnt Proteins
• beta Catenin
• hydnocarpin

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, toxicity)
• Axin Protein (antagonists & inhibitors, genetics, metabolism)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Colonic Neoplasms (metabolism, pathology)
• Flavonolignans (chemistry, isolation & purification, toxicity)
• Humans
• Lignans (chemistry)
• Lonicera (chemistry, metabolism)
• RNA Interference
• RNA, Small Interfering (metabolism)
• Wnt Proteins (metabolism)
• Wnt Signaling Pathway (drug effects)
• beta Catenin (metabolism)