Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer.

Abstract

Lung metastasis is one of the greatest challenges for breast cancer treatment. Here, a nanodiamonds (NDs)-mediated doxorubicin (DOX) delivery system was first designed to inhibit the lung metastasis of breast cancer effectively. DOX was non-covalently bound to NDs via physical adsorption in an aqueous solution, then DSPE-PEG 2K was coated to the NDs-DOX complex (NDX) to increase the dispersibility and prolong the circulation time. DSPE-PEG 2K coating NDX (DNX) displayed high drug loading and excellent ability to deliver DOX to the nucleus, thereby significantly enhancing cytotoxicity and inducing cell apoptosis. Furthermore, DNX showed good histocompatibility and could improve drug accumulation in lung, as a result, markedly inhibited the lung metastasis of breast cancer. The high anti-metastasis efficacy with the decreased systemic toxicity suggested that DNX could be a promising drug delivery system for the therapy of lung metastasis of breast cancer.

• Authors: Jisheng Xiao, Xiaopin Duan, Qi Yin, Zhiwen Zhang, Haijun Yu, Yaping Li
• Journal: Biomaterials (Biomaterials) Vol. 34 Issue 37 Pg. 9648-56 (Dec 2013) ISSN: 1878-5905 [Electronic] Netherlands
• PMID: 24016858 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Antibiotics, Antineoplastic
• Drug Carriers
• Nanodiamonds
• Doxorubicin

Topics

• Animals
• Antibiotics, Antineoplastic (administration & dosage, pharmacokinetics, therapeutic use)
• Breast (drug effects, pathology)
• Breast Neoplasms (drug therapy, pathology)
• Cell Line, Tumor
• Doxorubicin (administration & dosage, pharmacokinetics, therapeutic use)
• Drug Carriers (chemistry)
• Female
• Humans
• Lung (drug effects, pathology)
• Lung Neoplasms (pathology, prevention & control, secondary)
• Mice
• Mice, Inbred BALB C
• Nanodiamonds (chemistry)
• Rats
• Rats, Sprague-Dawley