Abstract | BACKGROUND: METHODS: Systematic literature search was done from PubMed, EMBASE, Google Scholar, EBSCO, Springer and CNKI databases without language or time limitation. Randomized controlled trials were enrolled for analyzing if they investigated the treatment of IC administration of tirofiban versus other conventional drugs for NR. RESULTS: Ten studies with 702 patients were included. Significantly, the treatment of tirofiban was more effective in improving the thrombolysis in myocardial infarction (TIMI) flow (OR 0.24, 95% CI 0.15-0.37, P < 0.00001) and reducing major adverse cardiovascular events ( MACE) (OR 0.09, 95% CI 0.05-0.18, P < 0.00001). There was a trend to increase the risk of bleeding, but the data of the result did not reach the statistical significance (OR 1.44, 95% CI 0.69-3.00, P = 0.32). CONCLUSIONS:
Tirofiban is more effective than conventional drugs for NR during PCI, but the potential risk of bleeding complication induced by tirofiban shouldn't be ignored during clinical practices.
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Authors | Tao Qin, Lu Xie, Meng-Hua Chen |
Journal | BMC cardiovascular disorders
(BMC Cardiovasc Disord)
Vol. 13
Pg. 68
(Sep 10 2013)
ISSN: 1471-2261 [Electronic] England |
PMID | 24016038
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- Platelet Aggregation Inhibitors
- Tyrosine
- Tirofiban
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Topics |
- Coronary Vessels
(drug effects)
- Humans
- Injections, Intra-Arterial
- No-Reflow Phenomenon
(drug therapy)
- Percutaneous Coronary Intervention
(adverse effects)
- Platelet Aggregation Inhibitors
(administration & dosage, adverse effects)
- Randomized Controlled Trials as Topic
(adverse effects, methods)
- Tirofiban
- Treatment Outcome
- Tyrosine
(administration & dosage, adverse effects, analogs & derivatives)
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