HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of propranolol on gastric microcirculation and acid secretion in portal hypertensive rats.

Abstract
Rats with chronic portal hypertension have an increased gastric mucosal blood flow and an impaired acid secretory response to pentagastrin stimulation. This study investigated the effects of propranolol, a drug widely used in the treatment of portal hypertension, on gastric mucosal blood flow and acid secretion in portal hypertensive rats with partial portal vein occlusion. In study I, gastric mucosal blood flow, measured by hydrogen gas clearance, and acid output were determined in basal conditions and after the administration of propranolol (0.3 mg/kg/min) or vehicle infusion in portal hypertensive and sham-operated rats. Gastric mucosal blood flow was significantly higher (p less than 0.005) in portal hypertensive rats than in sham-operated rats, and it was significantly reduced (p less than 0.05) after propranolol infusion in portal hypertensive rats (39 +/- 2 vs. 35 +/- 3 ml/min/100 gm). Basal acid output was not significantly modified with propranolol infusion, either in portal hypertensive or sham-operated animals. In study II, acid output was measured in portal hypertensive rats in basal conditions, during pentagastrin (20 micrograms/kg/hr) infusion and after the combined infusion of pentagastrin and propranolol (or vehicle). Pentagastrin infusion significantly increased (p less than 0.001) acid output, but propranolol did not modify stimulated gastric acid secretion. In conclusion, propranolol induced a slight but significant reduction in gastric mucosal blood flow and did not change basal or stimulated gastric acid secretion.
AuthorsJ M Piqué, P Pizcueta, R M Pérez Ayuso, J Bosch
JournalHepatology (Baltimore, Md.) (Hepatology) Vol. 12 Issue 3 Pt 1 Pg. 476-80 (Sep 1990) ISSN: 0270-9139 [Print] United States
PMID2401453 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Propranolol
  • Pentagastrin
Topics
  • Animals
  • Disease Models, Animal
  • Drug Interactions
  • Gastric Acid (metabolism)
  • Gastric Mucosa (blood supply, drug effects, metabolism)
  • Hypertension, Portal (etiology, physiopathology)
  • Male
  • Microcirculation (drug effects)
  • Pentagastrin (pharmacology)
  • Propranolol (pharmacology)
  • Rats
  • Rats, Inbred Strains

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: