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Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs.

Abstract
Asthmatic inflammation is mediated by a type 2 helper T cell (Th2) cytokine response, and blocking Th2 cytokine production is proven to have a potent therapeutic effect against asthmatic inflammation. Using IL-4-green fluorescent protein (GFP) reporter mice, we demonstrated that Bavachinin, a single compound isolated from a Chinese herb, significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model. Furthermore, we demonstrated that this chemical selectively affects the level of GATA-3, most likely by affecting the stability of GATA-3 mRNA. Our results demonstrate, for the first time, the potential therapeutic value of this single compound derived from Chinese herbs.
AuthorsXi Chen, Ti Wen, Jun Wei, Zhenzhou Wu, Puyue Wang, Zhangyong Hong, Liqing Zhao, Bin Wang, Richard Flavell, Shumei Gao, Min Wang, Zhinan Yin
JournalCellular & molecular immunology (Cell Mol Immunol) Vol. 10 Issue 6 Pg. 497-505 (Nov 2013) ISSN: 2042-0226 [Electronic] China
PMID24013845 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cytokines
  • Drugs, Chinese Herbal
  • Flavonoids
  • GATA3 Transcription Factor
  • Gata3 protein, mouse
  • RNA, Messenger
  • bavachinin
Topics
  • Animals
  • Asthma (complications, drug therapy, immunology, physiopathology)
  • Bronchial Hyperreactivity (drug therapy)
  • Cell Differentiation (drug effects, immunology)
  • Cytokines (metabolism)
  • Disease Models, Animal
  • Drugs, Chinese Herbal (isolation & purification, pharmacology, therapeutic use)
  • Female
  • Flavonoids (isolation & purification, pharmacology, therapeutic use)
  • GATA3 Transcription Factor (genetics, metabolism)
  • Hypersensitivity (complications, drug therapy, immunology)
  • Inflammation (complications, drug therapy, immunology)
  • Lung (drug effects, immunology, pathology)
  • Male
  • Mice
  • Mice, Inbred BALB C
  • RNA Stability (drug effects)
  • RNA, Messenger (genetics, metabolism)
  • Th2 Cells (cytology, drug effects, immunology)

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