Abstract |
We have evaluated the potential of four synthetic peptides (denoted HH-2, 1002, 1006, 1018) with a distant relationship to the host defense peptide bovine bactenecin dodecapeptide for their ability to prevent genital infections with herpes simplex virus type 2 (HSV-2) in mice. All four peptides showed antiviral properties in vitro and reduced HSV-2 infection of Vero cells in a dose-dependent manner. Detailed analysis showed that the peptides were able to interfere with both viral attachment and entry, but not with replication post-entry, and were effective antivirals also when HSV-2 was introduced in human semen. Two of the peptides proved especially effective in reducing HSV-2 infection also in vivo. When admixed with virus prior to inoculation, both HH-2 and 1018 reduced viral replication and disease development in a genital model of HSV-2 infection in mice, and also when using very high infectious doses of HSV-2. These data show that peptides HH-2 and 1018 have antiviral properties and can be used to prevent genital herpes infection in mice.
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Authors | Andrey Shestakov, Håvard Jenssen, Robert E W Hancock, Inger Nordström, Kristina Eriksson |
Journal | Antiviral research
(Antiviral Res)
Vol. 100
Issue 2
Pg. 455-9
(Nov 2013)
ISSN: 1872-9096 [Electronic] Netherlands |
PMID | 24012999
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier B.V. All rights reserved. |
Chemical References |
- Antiviral Agents
- Peptides, Cyclic
- bactenecin
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Topics |
- Animals
- Antiviral Agents
(pharmacology, therapeutic use)
- Chemoprevention
(methods)
- Chlorocebus aethiops
- Disease Models, Animal
- Herpes Genitalis
(prevention & control)
- Herpesvirus 2, Human
(drug effects, physiology)
- Mice
- Microbial Sensitivity Tests
- Peptides, Cyclic
(pharmacology, therapeutic use)
- Treatment Outcome
- Vero Cells
- Virus Internalization
(drug effects)
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