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Synthetic analogues of bovine bactenecin dodecapeptide reduce herpes simplex virus type 2 infectivity in mice.

Abstract
We have evaluated the potential of four synthetic peptides (denoted HH-2, 1002, 1006, 1018) with a distant relationship to the host defense peptide bovine bactenecin dodecapeptide for their ability to prevent genital infections with herpes simplex virus type 2 (HSV-2) in mice. All four peptides showed antiviral properties in vitro and reduced HSV-2 infection of Vero cells in a dose-dependent manner. Detailed analysis showed that the peptides were able to interfere with both viral attachment and entry, but not with replication post-entry, and were effective antivirals also when HSV-2 was introduced in human semen. Two of the peptides proved especially effective in reducing HSV-2 infection also in vivo. When admixed with virus prior to inoculation, both HH-2 and 1018 reduced viral replication and disease development in a genital model of HSV-2 infection in mice, and also when using very high infectious doses of HSV-2. These data show that peptides HH-2 and 1018 have antiviral properties and can be used to prevent genital herpes infection in mice.
AuthorsAndrey Shestakov, Håvard Jenssen, Robert E W Hancock, Inger Nordström, Kristina Eriksson
JournalAntiviral research (Antiviral Res) Vol. 100 Issue 2 Pg. 455-9 (Nov 2013) ISSN: 1872-9096 [Electronic] Netherlands
PMID24012999 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier B.V. All rights reserved.
Chemical References
  • Antiviral Agents
  • Peptides, Cyclic
  • bactenecin
Topics
  • Animals
  • Antiviral Agents (pharmacology, therapeutic use)
  • Chemoprevention (methods)
  • Chlorocebus aethiops
  • Disease Models, Animal
  • Herpes Genitalis (prevention & control)
  • Herpesvirus 2, Human (drug effects, physiology)
  • Mice
  • Microbial Sensitivity Tests
  • Peptides, Cyclic (pharmacology, therapeutic use)
  • Treatment Outcome
  • Vero Cells
  • Virus Internalization (drug effects)

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