The value of serum albumin as a novel independent marker for prognosis in patients with endometrial cancer.
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| Abstract | OBJECTIVE:
Hypoalbuminemia, a known marker for malnutrition and increased morbidity and mortality, has been associated with impaired prognosis in different cancer entities. The present study investigates the prognostic value of pre-treatment serum albumin levels for survival in patients with endometrial cancer. STUDY DESIGN: Within the present cohort study, we evaluated 337 consecutive patients with endometrial cancer and investigated the association of pre-treatment serum albumin levels and clinical-pathological parameters. We performed univariate log-rank tests and multivariable Cox regression models to assess the association between pre-treatment serum albumin levels and survival. RESULTS: Pre-treatment serum albumin levels were inversely proportionally associated with FIGO tumor stage, histological grade, and patients' age. In a multivariable analysis pre-treatment serum albumin levels (p = 0.02 and p = 0.001), FIGO tumor stage (p < 0.001 and p < 0.001), and histological grade (p = 0.002 and p < 0.001) were independently associated with disease-free and progression-free survival, respectively. CONCLUSION: Pre-treatment serum albumin is a novel and independent prognostic parameter for disease-free and progression-free survival in patients with endometrial cancer.
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| Authors | Veronika Seebacher, Christoph Grimm, Alexander Reinthaller, Georg Heinze, Clemens Tempfer, Lukas Hefler, Stephan Polterauer |
| Journal | European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 171 Issue 1 Pg. 101-6 (Nov 2013) ISSN: 1872-7654 [Electronic] Ireland |
| PMID | 24011381 (Publication Type: Journal Article) |
| Copyright | Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
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