Partially reversible cardiomyopathy after renal transplant associated with anti-troponin I antibodies.

Abstract

Cardiomyopathy associated with dialysis has been shown to be reversible in some cases. A 58-year-old female patient with polycystic renal disease and end-stage renal disease had a renal transplant after 9 years on hemodialysis. Dilated cardiomyopathy with depressed left ventricular ejection fraction markedly improved after transplantation, with normalization of the ejection fraction. High titers for anti-troponin I antibodies were measured: IgG 1:640, IgM 1:80. In our case, the presence of anticardiac (anti-troponin I) antibodies may suggest that the syndrome of reversible cardiomyopathy seen after renal transplantation is associated with immunosuppression therapy acting on immunological mechanisms previously at play.

• Authors: José Pedro L Nunes, Maria do Sameiro Faria, Susana Sampaio, José Quintas, Hugo A Katus, Ziya Kaya
• Journal: Cardiology (Cardiology) Vol. 126 Issue 3 Pg. 173-4 ( 2013) ISSN: 1421-9751 [Electronic] Switzerland
• PMID: 24009043 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2013 S. Karger AG, Basel.

Chemical References

• Antibodies
• Immunosuppressive Agents
• Troponin I

Topics

• Antibodies (metabolism)
• Cardiomyopathy, Dilated (drug therapy, immunology)
• Female
• Humans
• Immunosuppressive Agents (therapeutic use)
• Kidney Failure, Chronic (surgery)
• Kidney Transplantation
• Middle Aged
• Polycystic Kidney Diseases (surgery)
• Renal Dialysis (adverse effects)
• Troponin I (immunology)