Effects of the tumor promoter 2-acetylaminofluorene and of 4-acetylaminofluorene on rat liver growth.

Abstract

2-Acetylaminofluorene (2-AAF) is a moderately cytotoxic drug which is nevertheless capable of promoting diethylnitrosamine-initiated rat liver carcinogenesis in the absence of detectable hepatotoxicity. 2-AAF does not stimulate net growth of the normal liver, but alters hepatocellular ploidy distributions (fewer binucleated and more diploid cells) in a manner indicative of altered growth control. The non-cytotoxic analogue 4-AAF induces a similar ploidy change, and also stimulates liver growth. The possibility should therefore be considered that both agents may specifically elicit a mononucleating growth response in normal liver, which in the case of 2-AAF is antagonized by a general (cytotoxic) growth inhibition. In the promotion of liver carcinogenesis, 2-AAF may act as a growth stimulant upon cytotoxicity-resistant initiated cells; cytotoxicity per se playing no causative role.

• Authors: P Gerlyng, P O Seglen
• Journal: Bulletin du cancer (Bull Cancer) Vol. 77 Issue 5 Pg. 461-6 ( 1990) ISSN: 0007-4551 [Print] France
• PMID: 2400817 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• 2-Acetylaminofluorene

Topics

• 2-Acetylaminofluorene (toxicity)
• Animals
• Carcinogens (pharmacology)
• Cell Division (drug effects)
• Cell Transformation, Neoplastic (chemically induced)
• Liver (cytology)
• Liver Neoplasms, Experimental (chemically induced)
• Ploidies
• Rats
• Rats, Inbred Strains