Type II Fp of human mitochondrial respiratory complex II and its role in adaptation to hypoxia and nutrition-deprived conditions.

Abstract

The flavoprotein (Fp) subunit of human mitochondrial succinate-ubiquinone reductase (SQR, complex II) has isoforms (type I, type II). Type II Fp is predominantly expressed in some cancer and fetal tissues and those tissues are often exposed to ischemia. The present study shows that complex II with type II Fp has lower optimal pH than complex II with type I Fp, and type II Fp mRNA expression was induced by ischemia. The result suggests complex II with type II Fp may function in cells with low mitochondrial matrix pH caused by ischemia and its function is related to cellular adaptation to ischemia.

• Authors: Chika Sakai, Eriko Tomitsuka, Makoto Miyagishi, Shigeharu Harada, Kiyoshi Kita
• Journal: Mitochondrion (Mitochondrion) Vol. 13 Issue 6 Pg. 602-9 (Nov 2013) ISSN: 1872-8278 [Electronic] Netherlands
• PMID: 24008124 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013. Published by Elsevier B.V. and Mitochondria Research Society.

Chemical References

• DNA Primers
• RNA, Messenger
• respiratory complex II
• Electron Transport Complex II
• SDHA protein, human

Topics

• Adaptation, Physiological
• Base Sequence
• DNA Primers
• Electron Transport Complex II (genetics, metabolism, physiology)
• Humans
• Hydrogen-Ion Concentration
• Hypoxia (physiopathology)
• Malnutrition (physiopathology)
• Mitochondria (metabolism)
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• RNA, Messenger (genetics)