[Intranasal co-administration of recombinant streptococcus group B polypeptides and influenza deltaNS1 vaccine].

Abstract

In the present work, the immunoadjuvant properties of the influenza deltaNS1 vaccine virus after intranasal administration in combination with recombinant GBS polypeptides was tested in mice. According to our data, co-administration of recombinant GBS polypeptides and influenza deltaNS1 vaccine resulted in the increase in the immunogenicity and protective efficacy of bacterial proteins. Combined vaccination with the GBS polypeptides and influenza deltaNS1 vaccine has a potential to be used not only for prophylaxis infections caused by SGB, but also for prevention of the bacterial complications of influenza.

• Authors: A-P S Shurygina, G F Leont'eva, K B Grabovskaia, T V Gupalova, I V Koroleva, T A Kramskaia, O I Kiselev, A Iu Egorov, A N Suvorov
• Journal: Voprosy virusologii (Vopr Virusol) 2013 May-Jun Vol. 58 Issue 3 Pg. 28-31 ISSN: 0507-4088 [Print] Russia (Federation)
• PMID: 24006630 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies, Bacterial
• Antibodies, Viral
• INS1 protein, influenza virus
• Influenza Vaccines
• Peptides
• Recombinant Proteins
• Streptococcal Vaccines
• Vaccines, Synthetic
• Viral Nonstructural Proteins

Topics

• Administration, Intranasal
• Animals
• Antibodies, Bacterial (blood, immunology)
• Antibodies, Viral (blood, immunology)
• Cross Protection
• Female
• Influenza A Virus, H1N1 Subtype (genetics, immunology)
• Influenza Vaccines (administration & dosage, genetics, immunology)
• Mice
• Mice, Inbred BALB C
• Orthomyxoviridae Infections (immunology, prevention & control, virology)
• Peptides (genetics, immunology)
• Recombinant Proteins (administration & dosage, genetics, immunology)
• Streptococcal Infections (immunology, microbiology, prevention & control)
• Streptococcal Vaccines (administration & dosage, genetics, immunology)
• Vaccination
• Vaccines, Synthetic
• Viral Nonstructural Proteins (deficiency, genetics)