HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparison of the enhancement of plasma glucose levels in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats by oral administration of sucrose or maple syrup.

Abstract
Maple syrup is used as a premium natural sweeter, and is known for being good for human health. In the present study, we investigate whether maple syrup is suitable as a sweetener in the management of type 2 diabetes using Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of type 2 diabetes mellitus. OLETF rats develop type 2 diabetes mellitus by 30 weeks of age, and 60-week-old OLETF rats show hyperglycemia and hypoinsulinemia via pancreatic β-cell dysfunction. The administration of sucrose or maple syrup following an OGT test increased plasma glucose (PG) levels in OLETF rats, but the enhancement in PG following the oral administration of maple syrup was lower than in the case of sucrose administration in both 30- and 60-week-old OLETF rats. Although, the insulin levels in 30-week-old OLETF rats also increased following the oral administration of sucrose or maple syrup, no increase in insulin levels was seen in 60-week-old OLETF rats following the oral administration of either sucrose or maple syrup. No significant differences were observed in insulin levels between sucrose- and maple syrup-administered OLETF rats at either 30 or 60 weeks of age. The present study strongly suggests that the maple syrup may have a lower glycemic index than sucrose, which may help in the prevention of type 2 diabetes.
AuthorsNoriaki Nagai, Yoshimasa Ito, Atsushi Taga
JournalJournal of oleo science (J Oleo Sci) Vol. 62 Issue 9 Pg. 737-43 ( 2013) ISSN: 1347-3352 [Electronic] Japan
PMID24005018 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Blood Glucose
  • Dietary Sucrose
  • Insulin
  • Nutritive Sweeteners
Topics
  • Acer
  • Administration, Oral
  • Animals
  • Blood Glucose (metabolism)
  • Diabetes Mellitus, Type 2 (blood, prevention & control)
  • Dietary Sucrose (administration & dosage, pharmacology)
  • Disease Models, Animal
  • Glucose Tolerance Test
  • Glycemic Index (drug effects)
  • Humans
  • Insulin (blood)
  • Male
  • Nutritive Sweeteners (administration & dosage, pharmacology)
  • Rats
  • Rats, Inbred OLETF

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: