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Insulin sensitizers in polycystic ovary syndrome.

Abstract
From the conceptual point of view, there are several reasons to expect that improvement of insulin sensitivity may produce several benefits in the treatment of a complex disorder like polycystic ovary syndrome (PCOS), including a decrease in insulin and androgen levels, improvement of metabolic comorbidities, and, finally, improved ovulation and fertility. This can be achieved with the help of specific agents, particularly metformin and thiazolidinediones. They may ease the suffering of women with PCOS because insulin resistance and hyperinsulinemia appear to be major contributors to the pathophysiology of the syndrome.
AuthorsRenato Pasquali, Alessandra Gambineri
JournalFrontiers of hormone research (Front Horm Res) Vol. 40 Pg. 83-102 ( 2013) ISSN: 1662-3762 [Electronic] Switzerland
PMID24002407 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2013 S. Karger AG, Basel.
Chemical References
  • Insulin
  • PPAR gamma
  • Thiazolidinediones
  • Clomiphene
  • Metformin
Topics
  • Animals
  • Clomiphene (administration & dosage)
  • Diabetes Mellitus, Type 2 (prevention & control)
  • Female
  • Humans
  • Hyperandrogenism (drug therapy)
  • Hyperinsulinism (drug therapy)
  • Insulin (metabolism)
  • Insulin Resistance (physiology)
  • Life Style
  • Menstrual Cycle (drug effects)
  • Metformin (pharmacokinetics, therapeutic use)
  • Ovulation (drug effects)
  • PPAR gamma (drug effects)
  • Polycystic Ovary Syndrome (drug therapy, physiopathology)
  • Thiazolidinediones (therapeutic use)

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