[Respiratory and cardiovascular responses to hypoxia under activation or blockade inhibitory transmission].

Abstract

Respiratory rhythm changes and hypoxic ventilatory responses were studied in anesthetized albino rats after administration GABA and adenosine receptor antagonists. Intracisternal microinjection of picrotoxin induced pathological periodic breathing. Picrotoxin intravenous administration caused the increase of individual resistance to acute hypoxia. Aminophylline administration exerted the opposite effect. After pretreatment of hydroxybutyrate we observed different types of respiratory reactions to adenosine antagonist injection, which probably depended on the value of arterial blood pressure and cerebral hemodynamics.

• Authors: N V Sanotskaya, D D Matsievskii, M A Lebedeva
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 2013 Apr-Jun Issue 2 Pg. 32-6 ISSN: 0031-2991 [Print] Russia (Federation)
• PMID: 24000711 (Publication Type: Journal Article)

Chemical References

• GABA Antagonists
• Hydroxybutyrates
• Purinergic P1 Receptor Antagonists
• Picrotoxin
• Aminophylline

Topics

• Aminophylline (administration & dosage, pharmacology)
• Animals
• Blood Pressure (drug effects)
• GABA Antagonists (administration & dosage, pharmacology)
• Hemodynamics (drug effects)
• Hydroxybutyrates (pharmacology)
• Hypoxia (physiopathology)
• Injections, Intravenous
• Male
• Picrotoxin (administration & dosage, pharmacology)
• Pulmonary Ventilation (drug effects)
• Purinergic P1 Receptor Antagonists (administration & dosage, pharmacology)
• Rats
• Respiratory Rate (drug effects)
• Synaptic Transmission (drug effects)