Differential drug response of panic and agoraphobic avoidance in a case of panic disorder.

Abstract

A case is presented of a patient with severe panic disorder and agoraphobia in whom initial treatment with clomipramine resulted in complete elimination of panic attacks, with no improvement in agoraphobic avoidance. The addition of phenelzine to the pre-existing clomipramine treatment resulted in rapid and complete disappearance of the agoraphobic avoidance. The possible implications of this case for our understanding of the neurobiological relationship between panic attacks and agoraphobia are discussed.

• Authors: E Klein, L Metz
• Journal: Acta psychiatrica Scandinavica (Acta Psychiatr Scand) Vol. 82 Issue 1 Pg. 86-7 (Jul 1990) ISSN: 0001-690X [Print] United States
• PMID: 2399827 (Publication Type: Case Reports, Journal Article)

Chemical References

• Clomipramine
• Phenelzine

Topics

• Adult
• Agoraphobia (drug therapy, psychology)
• Arousal (drug effects)
• Clomipramine (administration & dosage)
• Drug Therapy, Combination
• Fear (drug effects)
• Humans
• Male
• Panic (drug effects)
• Phenelzine (administration & dosage)