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Vitamin E prevents hyperoxia-induced loss of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor proteins in the rat neuronal cytoplasm.

Abstract
This study examines the ability of vitamin E to inhibit hyperoxia-induced loss of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) proteins in the neuronal cytoplasm. Here, the effects of vitamin E on hyperoxia-induced changes in the expressions of N-ethylmaleimide-sensitive factor (NSF) and soluble NSF-attachment protein α (α-SNAP) in the rat brain were analyzed. When rats were subjected to hyperoxia, the expression of both SNARE proteins was markedly decreased compared to normal rats. Vitamin E significantly inhibited the decrease in the expression of NSF in rats subjected to hyperoxia. Rats showed the tendency to improve the loss of α-SNAP by vitamin E-supplementation, although it was not statistically significant. On the other hand, vitamin E deficient rats showed marked loss of these proteins in the brain in the absence of oxidative stress. These results suggest that hyperoxia induces a loss of SNARE proteins, which are involved in membrane docking between synaptic vesicles and pre-synaptic membranes, and that vitamin E prevents the oxidative damage of SNARE proteins. Consequently, it is implied that vitamin E inhibits impaired neurotransmission caused by oxidative stress through the prevention of oxidative damage to SNARE proteins by probably its antioxidant effect.
AuthorsNozomi Kaneai, Koji Fukui, Taisuke Koike, Shiro Urano
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 36 Issue 9 Pg. 1500-2 ( 2013) ISSN: 1347-5215 [Electronic] Japan
PMID23995663 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Nsf protein, rat
  • SNARE Proteins
  • Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
  • Vitamin E
  • N-Ethylmaleimide-Sensitive Proteins
Topics
  • Animals
  • Antioxidants (pharmacology)
  • Brain (drug effects, metabolism)
  • Cytoplasm (metabolism)
  • Hyperoxia (metabolism)
  • Male
  • N-Ethylmaleimide-Sensitive Proteins (metabolism)
  • Oxidative Stress (drug effects)
  • Rats
  • Rats, Wistar
  • SNARE Proteins (metabolism)
  • Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins (metabolism)
  • Synaptosomes (metabolism)
  • Vitamin E (pharmacology)

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