Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: New and improved topical formulations have emerged as effective tools to treat chronic refractory pain. In addition to formulations manufactured by the pharmaceutical industry, there has been a recent interest in mixed topical products by local, regional and national compounding pharmacies. This review will focus on advances in topical analgesics, especially their role as an effective analgesic in nociceptive and neuropathic refractory pain states. We will explore topical analgesics' mechanisms of action and their efficacy as opioid-sparing formulations. SUMMARY: This review will allow physicians to understand the role of topical agents in the treatment of intractable pain syndromes. Increasing medical providers' familiarity with these agents will allow their incorporation as part of a complex analgesic regimen for an improved pain management plan benefiting the patient population at large.
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Authors | Magdalena Anitescu, Honorio T Benzon, Charles E Argoff |
Journal | Current opinion in anaesthesiology
(Curr Opin Anaesthesiol)
Vol. 26
Issue 5
Pg. 555-61
(Oct 2013)
ISSN: 1473-6500 [Electronic] United States |
PMID | 23995062
(Publication Type: Journal Article, Review)
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Chemical References |
- Analgesics
- Anesthetics, Local
- Anti-Inflammatory Agents, Non-Steroidal
- Capsaicin
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Topics |
- Administration, Topical
- Analgesics
(administration & dosage)
- Anesthetics, Local
(administration & dosage)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Capsaicin
(administration & dosage)
- Humans
- Pain, Intractable
(drug therapy)
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