Targeting the somatostatin receptor in pituitary and neuroendocrine tumors.

Neuroendocrine and pituitary tumors are uncommon tumors that develop from cells of the (neuro-)endocrine system. They can secrete hormones, leading to typical symptoms and syndromes. The cornerstone of antisecretory treatment for neuroendocrine and growth hormone-secreting pituitary tumors consists of somatostatin analogs, which target the somatostatin receptors that are expressed on the tumor cell membrane. Somatostatin analogs activate the second messenger pathways that inhibit hormone secretion and may also delay tumor growth.
Recent developments in the field of somatostatin analogs and promising new angles in neuroendocrine tumor treatment are discussed. The recently approved somatostatin analog pasireotide and promising new analogs KE108 and somatoprim are reviewed. Further, innovative developments in the field of receptor manipulation, such as epigenetic manipulation and viral somatostatin receptor subtype-2 expression vectors, are discussed, as well as oncolytic viruses specifically targeting neuroendocrine tumor cells.
In addition to the development of novel somatostatin analogs and refining treatment with existing somatostatin analogs, alternative treatments targeting the somatostatin receptors that aim at increasing the number of somatostatin receptors should be explored as well, thereby broadening treatment perspectives and increasing options for prolonging survival.
AuthorsMarije J Veenstra, Wouter W de Herder, Richard A Feelders, Leo J Hofland
JournalExpert opinion on therapeutic targets (Expert Opin Ther Targets) Vol. 17 Issue 11 Pg. 1329-43 (Nov 2013) ISSN: 1744-7631 [Electronic] England
PMID23991721 (Publication Type: Journal Article, Review)
Chemical References
  • Receptors, Somatostatin
  • Amino Acid Sequence
  • Drug Delivery Systems
  • Humans
  • Neuroendocrine Tumors (drug therapy, metabolism)
  • Pituitary Neoplasms (drug therapy, metabolism)
  • Receptors, Somatostatin (chemistry, drug effects, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: