Peptides' role in autism with emphasis on exorphins.

Abstract

PROBLEM:

The nature of the peptides found increased in urine from autism needs verification of their structure, especially those that show opioid activity.

METHODS:

The peptides were separated on reverse phase C-18 HPLC in Trifluoroacetic acid-acetonitril gradients. Peaks eluting where synthetic opioids appear, and peaks that are common to most autistic children were analyzed by mass spectrometry and fragmentation pattern on a quadropole mass-spectrometer.

RESULTS:

We could demonstrate exorphins in the urine from autistic children, and their length varied from one patient to the next.

CONCLUSION:

Exorphins are found in urine of autistic children and may account for their symptoms.

• Authors: Karl L Reichelt, Dag Tveiten, Anne-Mari Knivsberg, Gunnar Brønstad
• Journal: Microbial ecology in health and disease (Microb Ecol Health Dis) Vol. 23 ( 2012) ISSN: 0891-060X [Print] Sweden
• PMID: 23990835 (Publication Type: Journal Article)