Health related quality of life among patients with chronic graft-versus-host disease in China.

Abstract

BACKGROUND:

Chronic graft-versus-host disease (GVHD), the commonest long-term complication after allogeneic hematopoietic stem cell transplantation (HSCT), has a negative impact on patients' health related quality of life (HRQoL). This study was designed to investigate the HRQoL in patients with chronic GVHD in China.

METHODS:

Two hundred and sixty-four patients with chronic GVHD who were ≥ 24 months post-HSCT and had been in continuous complete remission since HSCT were enrolled in this retrospective study. HRQoL was evaluated using an SF-36 questionnaire. Multivariate analysis was used to identify the factors that affect HRQoL in patients with chronic GVHD.

RESULTS:

HRQoL in patients categorized as having mild and moderate chronic GVHD was significantly better than in those in the severe category. In the moderate chronic GVHD category, markedly poorer HRQoL was observed in patients with both multiple organ involvement and more severe organ impairment than in those without these factors. According to multivariate analysis, chronic GVHD severity had the greatest significant negative impact on patients' HRQoL; whereas being female was associated with a negative impact on psychological health.

CONCLUSION:

Chronic GVHD severity strongly correlates with negative impacts on patients' HRQoL.

• Authors: Xiao-dong Mo, Lan-ping Xu, Dai-hong Liu, Yu-hong Chen, Xiao-hui Zhang, Huan Chen, Wei Han, Yu Wang, Feng-rong Wang, Jing-zhi Wang, Kai-yan Liu, Xiao-jun Huang
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 126 Issue 16 Pg. 3048-52 (Aug 2013) ISSN: 2542-5641 [Electronic] China
• PMID: 23981610 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Chronic Disease
• Female
• Graft vs Host Disease (psychology)
• Humans
• Male
• Middle Aged
• Quality of Life
• Retrospective Studies
• Severity of Illness Index