Liver transplantation for acute liver failure caused by macrophage activation syndrome.

Abstract

Macrophage activation syndrome (MAS) is a rare, potentially fatal condition, which most frequently complicates rheumatological conditions and is often associated with liver dysfunction. In this case report of a patient with MAS, acute liver failure developed despite conventional immunosuppressive therapy. Liver transplantation resulted in rapid recovery and the patient has remained well for six years. A recent diagnosis of Adult Onset Still's Disease (AOSD) provides additional supporting evidence that the initial presentation was caused by MAS. While transplantation in the context of systemic disease remains controversial, this first reported case of successful adult liver transplantation for acute liver failure caused by MAS raises an interesting clinical dilemma.

• Authors: James Orr, Yvonne Bury, Mark Hudson, Steven Masson
• Journal: Transplant international : official journal of the European Society for Organ Transplantation (Transpl Int) Vol. 26 Issue 11 Pg. e105-8 (Nov 2013) ISSN: 1432-2277 [Electronic] Switzerland
• PMID: 23981123 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 Steunstichting ESOT. Published by John Wiley & Sons Ltd.

Topics

• Adult
• Humans
• Liver Failure, Acute (etiology, surgery)
• Liver Transplantation
• Macrophage Activation Syndrome (complications)
• Male
• Still's Disease, Adult-Onset (complications)