Once-daily naftifine cream 1% in the treatment of tinea cruris and tinea corporis.

Abstract

Seventy patients with tinea cruris or tinea corporis were treated with naftifine cream 1% or vehicle once daily for 4 weeks in this double-blind, randomized study. After two weeks, the patients using naftifine had a significantly higher mycologic cure rate than the vehicle-treated patients (79% vs. 31%, p less than 0.001), and they showed significantly better resolution of signs and symptoms. Statistically significantly differences favoring naftifine over its vehicle were found throughout the treatment period and 2 weeks posttreatment.

• Authors: R E Jordon, R P Rapini, I H Rex Jr, H I Katz, J G Hickman, J W Bard, R S Medansky, D A Lew-Kaya, J Sefton, R E DeGryse
• Journal: International journal of dermatology (Int J Dermatol) 1990 Jul-Aug Vol. 29 Issue 6 Pg. 441-2 ISSN: 0011-9059 [Print] England
• PMID: 2397973 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Amines
• Antifungal Agents
• Ointments
• Allylamine
• naftifine

Topics

• Adolescent
• Adult
• Aged
• Allylamine (administration & dosage, analogs & derivatives, therapeutic use)
• Amines (therapeutic use)
• Antifungal Agents (administration & dosage, therapeutic use)
• Double-Blind Method
• Female
• Groin
• Humans
• Male
• Middle Aged
• Ointments
• Random Allocation
• Tinea (drug therapy)