Sperm-oolemmal interaction: role of the Arg-Gly-Asp (RGD) adhesion peptide.

Abstract

The Arg-Gly-Asp tripeptide (RGD) plays a widespread role in cell-to-cell and cell-to-matrix recognition. We demonstrated that an RGD-containing peptide (Arg-Gly-Asp-Val, RGDV) inhibits both oolemmal binding and penetration of zona-free hamster eggs by human spermatozoa in vitro when added to the incubation medium. These results suggest that RGD-containing proteins may play a role in sperm-oolemmal interactions required for fertilization.

• Authors: R A Bronson, F Fusi
• Journal: Fertility and sterility (Fertil Steril) Vol. 54 Issue 3 Pg. 527-9 (Sep 1990) ISSN: 0015-0282 [Print] United States
• PMID: 2397797 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Oligopeptides
• arginyl-glycyl-aspartic acid
• glycyl-arginyl-glycyl-glutamyl-seryl-proline

Topics

• Animals
• Cell Adhesion (drug effects, physiology)
• Cricetinae
• Female
• Male
• Oligopeptides (physiology)
• Ovum (drug effects, physiology)
• Sperm-Ovum Interactions (drug effects, physiology)
• Spermatozoa (drug effects, physiology)