Intravenous application of a primary sevoflurane metabolite improves outcome in murine septic peritonitis: first results.
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| Abstract |
Volatile anesthetics are known to have immunomodulatory effects in conditions of organ injury. A recent study in an experimental sepsis model has shown remarkably improved survival when mice were exposed to volatile anesthetics. In the present study, we show that hexafluoroisopropanol - a water-soluble primary sevoflurane metabolite - has beneficial effects on the overall survival in a murine model of cecal ligation and puncture. Seven-day survival as well as tissue damage markers including transaminases and high mobility group box protein-1 were assessed as measures of end organ damage. In animals undergoing cecal ligation and puncture procedure hexafluoroisopropanol conditioning - but not late postconditioning 24 hours after sepsis induction - significantly increased survival rate (17% vs. 77%, p = 0.037) and attenuated secretion of organ damage markers. This study shows survival benefits by administration of the metabolite of a volatile anesthetic. If successfully translated, hexafluoroisopropanol might offer interesting therapeutic opportunities in the future treatment of abdominal sepsis.
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| Authors | Inge K Herrmann, Maricela Castellon, David E Schwartz, Melanie Hasler, Martin Urner, Guochang Hu, Richard D Minshall, Beatrice Beck-Schimmer |
| Journal | PloS one (PLoS One) Vol. 8 Issue 8 Pg. e72057 ( 2013) ISSN: 1932-6203 [Electronic] United States |
| PMID | 23977207 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't) |
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