Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells.

Abstract

The anticarcinogenic activity of synthetic 1-O-octadecyl-2,3-dibutyroilglycerol (D-SCAKG) in tumor-cell line of colonocytes (SW620) was performed. The effect of the previously digested D-SCAKG under in vitro intestinal conditions was compared to the bioactivity of non-digested D-SCAKG. Antiproliferative activity of each individual product from digestion (1-O-octadecyl-2-butyroilglycerol; 1-O-octadecyl glycerol; butyric acid) was also performed. The impact of solubilization of lipid products within micellar structures was also tested. The 1-O-octadecyl glycerol was the most active compound, followed by 1-O-octadecyl-2-butyroilglycerol, D-SCAKG and butyric acid. The 1-O-octadecyl glycerol and butyric acid were the only molecules that showed antiproliferative effect in absence of micelles. Digested D-SCAKG was 4-fold more effective than non-digested D-SCAKG. A synergism between 1-O-octadecyl-2-butyroilglycerol and 1-O-octadecyl glycerol was evidenced. As summary, the synthetic D-SCAKG seems to be an interesting antitumoral lipid against colonocytes, especially after previous intestinal digestion, and mainly due to the synergism of the major products, namely 1-O-octadecyl-2-butyroilglycerol and 1-O-octadecyl glycerol. At the same time, 1-O-octadecyl-2-butyroilglycerol would constitute a stable esterified form of butyric acid for its vehiculization.

• Authors: S Molina, M I Moran-Valero, D Martin, L Vázquez, T Vargas, C F Torres, A Ramirez de Molina, G Reglero
• Journal: Chemistry and physics of lipids (Chem Phys Lipids) 2013 Oct-Nov Vol. 175-176 Pg. 50-6 ISSN: 1873-2941 [Electronic] Ireland
• PMID: 23973778 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Anticarcinogenic Agents
• Butyric Acid
• Glycerol

Topics

• Anticarcinogenic Agents (chemistry, pharmacology)
• Butyric Acid (chemistry, pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Colonic Neoplasms (drug therapy)
• Glycerol (chemistry, pharmacology)
• Humans